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Population Stratification

Definition
AI-generated

Population stratification is confounding caused by ancestry-related allele frequency differences that correlate with the phenotype.

Topics
GWAS
Related
Ancestry Ethnicity Fixation index (FST)

Why it matters in GWAS

If not controlled, it can produce inflated test statistics and spurious associations.

Example usage

"Cross-cohort analyses modeled Population Stratification to improve transferability and reduce population-structure confounding."

Ancestry Ethnicity Fixation index (FST) Fixation Index Genomic Inflation Factor Genome-Wide Association Study (GWAS) Polygenic Risk Score (PRS) Principal Component Analysis (PCA) Race Relatedness and Sample Structure Trans-Ancestry GWAS
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Borrell LN, et al. (2021). Race and genetic ancestry in medicine—a time for reckoning with racism. N Engl J Med.
  • Price AL, et al. (2006). Principal components analysis corrects for stratification in GWAS.
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