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Transcription Factor (TF)

Definition
AI-generated

A transcription factor (TF) is a protein that binds DNA (and often partners with cofactors) to activate or repress transcription of target genes.

Topics
Molecular biology
Synonyms
TF
Related
ChIP-seq (Chromatin Immunoprecipitation Sequencing) Cis-Regulatory Element Gene Regulatory Network (GRN)

Why it matters in GWAS

Noncoding associations often fall near TF binding motifs or ChIP-seq peaks; identifying the relevant TF can motivate allele-specific binding tests, CRISPR edits of motifs, and integration with chromatin QTL or single-cell programs.

Example usage

"The lead variant altered a predicted binding site for a lymphoid-lineage transcription factor."

ChIP-seq (Chromatin Immunoprecipitation Sequencing) Cis-Regulatory Element Gene Regulatory Network (GRN) Promoter Transcription Start Site (TSS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lambert SA, et al. (2018). The human transcription factors. Cell.
← Transcription Transcription Start Site (TSS) →

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