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Gene Regulatory Network (GRN)

Definition
AI-generated

A gene regulatory network (GRN) is a graph representation of regulatory relationships among genes and other molecules—commonly transcription factors, signaling proteins, and chromatin regulators—and their targets.

Topics
Molecular biology
Synonyms
GRN gene regulatory networks
Related
Cis-Regulatory Element Gene Regulatory Network Inference Pathway Analysis

Why it matters in GWAS

Placing a GWAS candidate gene within a GRN suggests upstream regulators and downstream effectors for follow-up experiments, pathway enrichment, and integration with single-cell or eQTL context.

Example usage

"The master regulator sat high in the macrophage GRN inferred from single-cell RNA-seq."

Cis-Regulatory Element Gene Regulatory Network Inference Pathway Analysis Transcription Factor (TF)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Davidson EH. (2010). The Regulatory Genome. Academic Press.
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