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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)

Definition
AI-generated

CRISPR–Cas systems are programmable nucleases (and related editors) used to cut or modify DNA or RNA at targeted sequences, enabling high-throughput perturbation screens and precise genome engineering in cells and model organisms.

Topics
Molecular biology
Related
Gene Therapy Expression Quantitative Trait Locus (eQTL) Functional Fine-Mapping

Why it matters in GWAS

CRISPR screens and targeted edits are used to test whether noncoding GWAS candidates regulate genes of interest, to build causal maps alongside QTL and eQTL evidence, and to model variant effects in vitro.

Example usage

"CRISPR perturbation of the candidate enhancer changed target-gene expression in the expected direction."

Gene Therapy Expression Quantitative Trait Locus (eQTL) Functional Fine-Mapping Noncoding Variant Perturb-seq Single-Cell Perturbation Genomics
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Doudna JA, Charpentier E. (2014). The new frontier of genome engineering with CRISPR-Cas9. Science.
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