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Recurrent Neural Network (RNN)

Definition
AI-generated

A recurrent neural network (RNN) processes sequential inputs with hidden states updated at each time step, sharing parameters across positions; practical variants such as LSTM and GRU gates mitigate vanishing gradients for long dependencies.

Why it matters in GWAS

RNNs and their gated variants model RNA sequence, chromatin profiles along the genome, and longitudinal EHR or wearable time series linked to genetic studies. For genomics, sequence order and strand must be defined consistently, and models should be checked for batch and ancestry effects analogous to other predictors.

Example usage

"The longitudinal LDL trajectory model used a gated RNN over clinic visits before testing SNP-by-trajectory association."

References

  • Hochreiter S, Schmidhuber J. (1997). Long short-term memory. Neural Comput.

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