Neural Network¶
A neural network is a parametric function built from layers of connected units (nodes) with adjustable weights; training uses labeled or unlabeled data and a loss function, typically optimized by gradient-based methods so the network approximates a mapping from inputs to outputs.
Why it matters in GWAS¶
Neural models appear in polygenic prediction, variant effect and splicing predictors, single-cell embedding and batch correction, and generative simulation of molecular or phenotypic data. Architecture choice, leakage from relatedness or population structure, and limited portability across ancestries affect whether gains over simpler linear or mixed models hold in genetic studies.
Example usage¶
"The phenotype imputation step compared elastic net baselines against a shallow neural network trained on the UK Biobank field dictionary."
Related terms¶
References¶
- Rumelhart DE, Hinton GE, Williams RJ. (1986). Learning representations by back-propagating errors. Nature.
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