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Orthologous

Definition
AI-generated

Orthologous genes or sequences are homologs that diverged because of a speciation event; see [Ortholog](ortholog.md).

Topics
Evolutionary genetics
Related
Ortholog Homology Phylogeny

Why it matters in GWAS

Orthologous mapping links human GWAS genes to experimentally tractable orthologs in other species.

Example usage

"The zebrafish orthologous locus recapitulated the craniofacial phenotype."

Ortholog Homology Phylogeny
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.
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