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Speciation

Definition
AI-generated

Speciation is the formation of reproductively isolated lineages—by geographic separation, ecological divergence, chromosomal change, or other barriers—so that gene flow between them ceases or is greatly reduced and they diverge as distinct species or incipient species over time.

Why it matters in GWAS

Comparative and non-model genetics use divergence between species or subspecies to interpret conserved regulatory elements and orthologous genes; human studies rarely test speciation directly but borrow phylogenetic and demographic models calibrated on related primates or mammals.

Example usage

"Downstream interpretation uses Speciation to connect statistical evidence with biological context."

References

  • Coyne JA, Orr HA. (2004). Speciation. Sinauer Associates.

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