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Missing Heritability

Definition
AI-generated

Missing heritability is the gap between heritability estimated from family-based designs and the smaller fraction explained by discovered variants or by measured SNPs in GWAS data.

Topics
Core genetics
Related
Broad-Sense Heritability Heritability Omnigenic Model

Why it matters in GWAS

It motivates sequencing, larger sample sizes, better imputation, and more careful interpretation of what standard GWAS can and cannot capture.

Example usage

"Despite many genome-wide significant loci, substantial missing heritability remained for the trait."

Broad-Sense Heritability Heritability Omnigenic Model Narrow-Sense Heritability SNP Heritability
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Manolio TA, et al. (2009). Finding the missing heritability of complex diseases. Nature.
← Missense Variant Mitochondrial DNA (mtDNA) →

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