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SNP Heritability

Definition
AI-generated

SNP heritability is the proportion of phenotypic variance explained by the SNPs included in, or tagged by, the data and model used in a GWAS analysis.

Topics
Core genetics
Related
Heritability LD Score Regression Liability Scale

Why it matters in GWAS

It summarizes how much trait variation is recoverable from common-variant data, informs power expectations, and is a standard output of methods such as GREML and LD score regression.

Example usage

"LD score regression estimated SNP heritability of the trait at 0.18 on the liability scale."

Heritability LD Score Regression Liability Scale Missing Heritability Narrow-Sense Heritability Observed Scale
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References

  • Yang J, et al. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nat Genet.
← Single Nucleotide Polymorphism (SNP) Single Nucleotide Variant (SNV) →

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