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Omnigenic Model

Definition
AI-generated

The omnigenic model proposes that for many complex traits, essentially all genes expressed in disease-relevant cells can influence the trait through highly interconnected regulatory networks, so that most genetic heritability is spread across subtle effects genome-wide rather than concentrated in a small set of core genes.

Topics
Evolutionary genetics
Related
Broad-Sense Heritability Genome-Wide Association Study (GWAS) Heritability

Why it matters in GWAS

It reframes why GWAS finds thousands of small-effect loci and why gene-level interpretation often requires context-specific networks, while still allowing a subset of “core” genes with stronger peripheral effects.

Example usage

"The methods explicitly include Omnigenic Model to support interpretation of the main findings."

Broad-Sense Heritability Genome-Wide Association Study (GWAS) Heritability Missing Heritability Pleiotropy Polygenic Risk Score (PRS) SNP Heritability
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Boyle EA, Li YI, Pritchard JK. (2017). An expanded view of complex traits: from polygenic to omnigenic. Cell.
  • Uffelmann E, et al. (2021). Genome-wide association studies. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-021-00056-9
← Oligonucleotide Open Reading Frame (ORF) →

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