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Broad-Sense Heritability

Definition
AI-generated

Broad-sense heritability is the proportion of phenotypic variance attributable to all genetic sources of variation, including additive, dominance, and interaction effects.

Topics
Core genetics
Related
Additive Genetic Model Heritability Missing Heritability

Why it matters in GWAS

Broad-sense heritability sets an upper bound on the fraction of trait variance explained by genetics, but it is usually not the direct target of standard SNP-based GWAS models.

Example usage

"Twin studies suggested high broad-sense heritability, whereas SNP-based estimates captured only the additive component tagged by common variants."

Additive Genetic Model Heritability Missing Heritability Narrow-Sense Heritability
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Visscher PM, Hill WG, Wray NR. (2008). Heritability in the genomics era. Nat Rev Genet.
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