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Positive Selection

Definition
AI-generated

Positive selection (Darwinian selection favoring new or standing beneficial variants) increases the frequency of alleles that raise fitness.

Topics
Evolutionary genetics
Related
Introgression Natural Selection Negative Selection

Why it matters in GWAS

Loci under recent or ongoing positive selection can show unusual LD, frequency spectra, or cross-population patterns; this complicates neutral models used in some scans and can tag variants involved in local adaptation or diet, pathogen defense, and other traits relevant to disease risk.

Example usage

"The sweep scan highlighted a long haplotype at the locus, consistent with recent positive selection in the ancestral population."

Introgression Natural Selection Negative Selection Selection Pressure
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Nielsen R. (2005). Molecular signatures of natural selection. Annu Rev Genet.
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