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Gene Flow

Definition
AI-generated

Gene flow is the movement of alleles between populations through migration and admixture, homogenizing allele frequencies and reducing genetic differentiation unless countered by drift or selection.

Topics
Evolutionary genetics
Related
Admixture Ancestry Fixation index (FST)

Why it matters in GWAS

Gene flow and admixture shape population structure that must be modeled in association tests; they also affect portability of GWAS and PRS across ancestry groups and the interpretation of F-statistics and demographic history.

Example usage

"We discussed how historical gene flow between neighboring groups could blur F_ST estimates used to stratify the meta-analysis."

Admixture Ancestry Fixation index (FST) Genetic Bottleneck Genetic Divergence Introgression Natural Selection Population Stratification Principal Component Analysis (PCA) Trans-Ancestry GWAS Wright's F_ST
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Slatkin M. (1987). Gene flow and the geographic structure of natural populations. Science.
  • Uffelmann E, et al. (2021). Genome-wide association studies. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-021-00056-9
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