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Inbreeding Coefficient (F)

Definition
AI-generated

The inbreeding coefficient F measures whether an individual carries two alleles identical by descent (IBD) more often than expected under random mating; for a locus or averaged across markers it quantifies departure from Hardy-Weinberg heterozygosity.

Topics
Core genetics
Related
F-Statistics Fixation Index Hardy-Weinberg Equilibrium (HWE)

Why it matters in GWAS

Extreme F can indicate sample swaps or population substructure; kinship and pedigree work also use F linked to diagonal entries of the genetic relationship matrix. The symbol F appears in both inbreeding and fixation index contexts (F_ST is different).

Example usage

"We removed samples with F-estimates more than three standard deviations from the cohort mean."

F-Statistics Fixation Index Hardy-Weinberg Equilibrium (HWE) Relatedness and Sample Structure Principal Component Analysis (PCA)
Related-term network

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References

← Inbreeding Inbreeding depression →

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