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Pedigree

Definition
AI-generated

A pedigree is a recorded family relationship structure showing how individuals are biologically related across generations.

Topics
Core genetics
Related
Cryptic Relatedness Identity by Descent (IBD) Kinship Coefficient

Why it matters in GWAS

Known pedigrees help distinguish expected from unexpected relatedness, support family-based designs, and provide a check against genotype-based relationship inference.

Example usage

"Genotype-based kinship estimates were compared with the reported pedigree before downstream QC."

Cryptic Relatedness Identity by Descent (IBD) Kinship Coefficient Mendelian Error Relatedness and Sample Structure Transmission Disequilibrium Test (TDT) Within-Family GWAS
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Manichaikul A, et al. (2010). Robust relationship inference in genome-wide association studies. Bioinformatics.
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