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Evolution

Definition
AI-generated

Evolution is change in allele frequencies in populations over generations, driven by mutation, recombination, natural selection, genetic drift, and gene flow.

Topics
Evolutionary genetics
Related
Ancestry Coalescent Theory Crossing Over

Why it matters in GWAS

Demographic history and selection leave footprints in allele frequencies and haplotype structure; ignoring them can bias association tests, while evolutionary reasoning helps interpret cross-population differences in effect sizes.

Example usage

"The discussion interprets Evolution cautiously after accounting for demographic history and sampling bias."

Ancestry Coalescent Theory Crossing Over Fixation Index Gene Flow Genetic Bottleneck Genetic Divergence Introgression Linkage Disequilibrium (LD) Minor Allele Frequency (MAF) Natural Selection Phylogeny
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Charlesworth B, Charlesworth D. (2010). Elements of Evolutionary Genetics. Roberts and Company.
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