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Cox Proportional Hazards Model

Definition
AI-generated

A semiparametric regression model for time-to-event data that relates covariates to the hazard multiplicatively while leaving the baseline hazard unspecified.

Topics
Regression and multivariate statistics
Synonyms
Cox model Proportional hazards model
Related
Censoring Hazard Hazard Ratio (HR)

Why it matters in GWAS

Cox models are widely used for incident disease in prospective cohorts and biobanks, producing per-allele log hazard ratios that can be meta-analysed similarly to log odds ratios when synthesis software supports them. Violations of proportionality (e.g. age-varying genetic effects) motivate time-varying coefficients, stratified baselines, or alternative parameterisations.

Example usage

"Time-to-event association was fit with a Cox proportional hazards model, adjusting for age, sex, and principal components."

Censoring Hazard Hazard Ratio (HR) Measure of Effect Survival Analysis Time-to-Event
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cox DR. (1972). Regression models and life-tables. J R Stat Soc Series B.
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