Skip to content

Read Depth

Definition
AI-generated

Read depth is the number of sequencing reads covering a given genomic position.

Topics
Sequencing and omics tech
Related
Coverage Read Variant Calling

Why it matters in GWAS

Low read depth increases genotype uncertainty, especially for heterozygotes and rare variants, while uneven depth can create systematic differences across samples or loci.

Example usage

"Variants with low read depth were excluded from the final call set before association testing."

Coverage Read Variant Calling
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
← Read Read mapping →

Last updated (UTC · Git history)