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Mean coverage

Definition
AI-generated

Mean coverage is the average sequencing depth over a defined scope (whole genome, exome, or target), often reported in fold coverage such as 30×.

Topics
Sequencing Data Analysis
Related
Breadth of coverage Coverage Read Depth

Why it matters in GWAS

Mean coverage drives power for rare alleles and genotype quality; cohorts with heterogeneous mean coverage need harmonized QC before association or joint calling.

Example usage

"Exome mean coverage was 80×, with 95% of targets above 20×."

Breadth of coverage Coverage Read Depth
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
← Mean Absolute Percentage Error (MAPE) Mean Squared Error (MSE) →

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