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Chromosome conformation capture on microarray (4C-on-chip)

Definition
AI-generated

In this on-chip 4C design, a single bait viewpoint is hybridized against targets on a microarray so contacts genome-wide are read out via microarray capture—different from circularized 4C-seq ([Circularized chromosome conformation capture (4C-seq)](circular-chromosome-conformation-capture.md)), which uses sequencing of circularized fragments.

Topics
Sequencing and omics tech
Related
Circularized chromosome conformation capture (4C-seq) Chromosome Conformation Capture 3C Hi C

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Chromosome conformation capture on microarray (4C-on-chip) linked the bait viewpoint to distal promoters in the locus."

Circularized chromosome conformation capture (4C-seq) Chromosome Conformation Capture 3C Hi C Chromatin
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
← Chromosome conformation capture (3C) Chromosome conformation capture carbon copy (5C) →

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