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Circularized chromosome conformation capture (4C-seq)

Definition
AI-generated

4C-seq uses circularized ligation products to enrich one-versus-all contact profiles from a single viewpoint (bait), distinct from the older microarray “4C-on-chip” design.

Topics
Sequencing and omics tech
Synonyms
Circular 4C (informal; disambiguate from microarray 4C-on-chip)
Related
Chromosome conformation capture on microarray (4C-on-chip) Chromosome Conformation Capture 3C Hi C

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Circularized chromosome conformation capture (4C-seq) from the GWAS locus bait recovered long-range contacts to candidate enhancers."

Chromosome conformation capture on microarray (4C-on-chip) Chromosome Conformation Capture 3C Hi C Promoter
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
← Circular chromosome Cis-acting →

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