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Chromosome conformation capture (3C)

Definition
AI-generated

Ligation-based assay quantifying contact frequency between two chosen loci in fixed nuclei—foundational for 3C family methods.

Topics
Sequencing and omics tech
Related
Hi C Chromosome Enhancer

Why it matters in GWAS

Bioinformatics methods determine how variants, expression, and epigenetic state are measured and summarized—shaping GWAS covariates, multi-omic integration, and functional follow-up.

Example usage

"Chromosome conformation capture data connected noncoding GWAS variants to distal gene promoters in relevant cell types."

Hi C Chromosome Enhancer
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lesk AM. (2019). Introduction to Bioinformatics. Oxford University Press.
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