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Chimeric read

Definition
AI-generated

A chimeric read (split read) reflects two or more disjoint genomic segments joined in one sequencing read, often from structural rearrangement, library chimera, or mapping across repeats.

Topics
Sequencing Data Analysis
Related
Properly paired reads Soft clipping Structural Variant

Why it matters in GWAS

Chimeric and supplementary alignments are key evidence for structural variants and fusion events in WGS pipelines.

Example usage

"Chimeric read support was required to confirm the predicted deletion breakpoint."

Properly paired reads Soft clipping Structural Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cameron DL, et al. (2019). Comprehensive evaluation of structural variant genotyping methods. Genome Biol.
← Chimera Chromatin Immunoprecipitation Sequencing (ChIP-seq) →

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