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Brisbane Plot

Definition
AI-generated

A Brisbane plot is a genome-wide scatter visualization where each point is an approximately independent association signal (for example after linkage disequilibrium-aware clumping or conditional analysis), plotted against chromosomal position.

Topics
Visualization
Related
Fine-Mapping gwaslab Manhattan Plot

Why it matters in GWAS

Dense polygenic architectures and pleiotropic loci can be hard to summarize with a standard Manhattan plot alone. Brisbane plots highlight genomic regions where many distinct signals cluster, complementing marginal Manhattan views when presenting large portfolios of fine-mapped or COJO-derived hits.

Example usage

"The Brisbane plot displayed thousands of nearly independent height loci and made regions of exceptional signal density obvious along each chromosome."

Fine-Mapping gwaslab Manhattan Plot Miami Plot
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Yengo L, et al. (2022). A saturated map of common genetic variants associated with human height. Nature. https://doi.org/10.1038/s41586-022-05275-y
  • GWASLab: Brisbane plot.
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