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Breadth of coverage

Definition
AI-generated

Breadth of coverage is the fraction of a target genome or region that meets a minimum depth threshold (for example the proportion of autosomes at ≥10×).

Topics
Sequencing Data Analysis
Related
Callable genome Coverage Mean coverage

Why it matters in GWAS

Low breadth leaves systematic gaps in difficult regions and can bias rare-variant and CNV analyses; reporting breadth alongside mean depth clarifies how completely a genome is represented.

Example usage

"Breadth of coverage at ≥20× exceeded 95% of the callable genome in the QC-pass subset."

Callable genome Coverage Mean coverage Read Depth
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
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