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Definition
AI-generated

A transcript is an RNA molecule produced from a locus, including precursor and mature forms; in genomics usage it often refers to a defined RNA isoform or annotated RNA feature (for example in GENCODE or RefSeq).

Topics
Molecular biology
Related
Alternative Splicing Canonical Transcript Gene expression

Why it matters in GWAS

Variant interpretation and eQTL/sQTL models are transcript-aware when they distinguish isoforms, junctions, and UTR usage—otherwise tissue-specific or splice-driven effects at a locus can be misattributed to whole-gene expression alone.

Example usage

"The risk haplotype was associated with a shorter 3′ UTR transcript isoform rather than total gene counts."

Alternative Splicing Canonical Transcript Gene expression Isoform RNA Sequencing (RNA-seq) Transcript Assembly Transcriptome
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • GTEx Consortium. (2020). The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science.
← Trans-regulatory element Transcript Assembly →

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