Skip to content

Gene expression

Definition
AI-generated

Gene expression is the process and measured output by which information from a gene is transcribed into RNA and often translated into protein; in omics studies it usually means RNA abundance or synthesis rate for a gene or transcript in a given sample.

Topics
Molecular biology Sequencing and omics tech
Related
Allele-specific expression (ASE) Expression Quantitative Trait Locus (eQTL) RNA Sequencing (RNA-seq)

Why it matters in GWAS

Expression integrates with eQTL and TWAS to connect noncoding and regulatory variants to altered gene programs, tissue context, and disease mechanisms beyond DNA-only association.

Example usage

"We tested whether the GWAS index SNP overlapped cis regulatory elements linked to reduced gene expression in liver."

Allele-specific expression (ASE) Expression Quantitative Trait Locus (eQTL) RNA Sequencing (RNA-seq) Transcript Transcript quantification Transcriptome Transcriptome-Wide Association Study (TWAS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • GTEx Consortium. (2020). The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science.
← Gene-environment interaction (GxE) Gene Flow →

Last updated (UTC · Git history)