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Targeted Sequencing

Definition
AI-generated

Targeted sequencing enriches and sequences a predefined set of genomic regions, such as candidate genes, custom panels, or loci of interest, rather than the whole exome or genome.

Topics
Sequencing and omics tech
Related
Fine-Mapping Variant Calling Whole-Exome Sequencing (WES)

Why it matters in GWAS

It is useful for fine-mapping, validation, and rare-variant follow-up in selected regions when whole-genome sequencing would be unnecessarily expensive.

Example usage

"After the discovery GWAS, targeted sequencing was used to characterize rare coding variants in the implicated genes."

Fine-Mapping Variant Calling Whole-Exome Sequencing (WES) Whole-Genome Sequencing (WGS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koboldt DC. (2020). Best practices for variant calling in clinical and population sequencing. Nat Methods.
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