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Tandem Repeat

Definition
AI-generated

A tandem repeat is a DNA sequence motif repeated head-to-tail multiple times at the same genomic locus.

Topics
Core genetics
Related
Microsatellite Minisatellite Repeat Expansion

Why it matters in GWAS

Tandem repeats are an important source of genetic variation that is often not well captured by SNP arrays or standard short-variant pipelines, despite sometimes having strong functional effects.

Example usage

"The associated region contained a tandem repeat that was not directly typed on the array."

Microsatellite Minisatellite Repeat Expansion Short Tandem Repeat (STR) Variable Number Tandem Repeat (VNTR)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Gymrek M. (2017). A genomic view of short tandem repeats. Curr Opin Genet Dev.
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