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System Prompt

Definition
AI-generated

A system prompt is a high-priority instruction block configured by the application (not the end user) that sets global behavior—role, safety rules, output format, and allowed tools—before user prompts are applied.

Topics
LLM and Agents
Synonyms
System message Developer message (API-specific)
Related
Genome-Wide Association Study (GWAS) Large Language Model (LLM) Prompt

Why it matters in GWAS

Consortium or IRB constraints (no individual-level data in logs, mandatory genome build disclosure) can be encoded in the system prompt so every analyst session inherits the same guardrails, complementing repo-specific skills.

Example usage

"The system prompt forbade pasting full VCF rows and required GRCh38 coordinates in all genomic examples."

Genome-Wide Association Study (GWAS) Large Language Model (LLM) Prompt Prompt Engineering Coding Assistant Skill
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • OpenAI. API reference: chat completions (role messages). https://platform.openai.com/docs/
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