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Synonymous Variant

Definition
AI-generated

A synonymous variant is a coding variant that changes the DNA sequence without changing the encoded amino acid.

Topics
Core genetics
Related
Missense Variant Splice-Site Variant Variant Annotation

Why it matters in GWAS

Synonymous variants are often interpreted as lower-impact than protein-altering variants, but they should not be assumed to be functionally irrelevant.

Example usage

"The associated coding SNP was annotated as a synonymous variant in the canonical transcript."

Missense Variant Splice-Site Variant Variant Annotation
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • McLaren W, et al. (2016). The Ensembl Variant Effect Predictor. Genome Biol.
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