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Institutional Review Board (IRB)

Definition
AI-generated

An Institutional Review Board (IRB) is an independent committee—constituted under applicable regulations—that reviews, approves, and oversees human subjects research conducted under an institution’s auspices.

Topics
Ethics, law & society
Related
Biobank Genetic Privacy Genome-Wide Association Study (GWAS)

Why it matters in GWAS

Genomic and biobank protocols (recruitment, broad data sharing, return of results, re-identification risk) typically require IRB review; methods sections and data-use agreements often cite IRB approval numbers and consent boundaries that constrain analyses.

Example usage

"The phenotype–genotype linkage was limited to variables described in the IRB-approved consent and data dictionary."

Biobank Genetic Privacy Genome-Wide Association Study (GWAS) Informed Consent
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • U.S. Department of Health and Human Services. Institutional Review Boards and the Protection of Human Subjects in Research. https://www.hhs.gov/ohrp/regulations-and-policy/guidance/index.html
  • Emanuel EJ, Wendler D, Grady C. (2000). What makes clinical research ethical? JAMA. https://doi.org/10.1001/jama.283.20.2701
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