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Common Variant

Definition
AI-generated

A common variant is a genetic variant with relatively high population frequency, often defined using a minor allele frequency threshold such as greater than 1% or 5%.

Topics
Core genetics
Related
Genotyping Array Minor Allele Frequency (MAF) Rare Variant

Why it matters in GWAS

Common variants are well represented on SNP arrays and imputation panels, which is why they dominate standard large-scale GWAS analyses.

Example usage

"Every common variant passing MAF filters was tested in the primary GWAS before rare-variant follow-up."

Genotyping Array Minor Allele Frequency (MAF) Rare Variant Single Nucleotide Polymorphism (SNP)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Gibson G. (2012). Rare and common variants: twenty arguments. Nat Rev Genet.
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