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Observed Scale

Definition
AI-generated

The observed scale is the scale on which a trait is directly analyzed in the sample, such as a measured quantitative phenotype or the sampled 0/1 case-control outcome.

Topics
Probability and inference
Related
Case-Control Study Heritability Liability Scale

Why it matters in GWAS

Observed-scale estimates are often the starting point for binary-trait heritability calculations before conversion to the liability scale.

Example usage

"We first estimated heritability on the observed scale and then transformed it to the liability scale."

Case-Control Study Heritability Liability Scale SNP Heritability
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lee SH, et al. (2011). Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet.
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