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Liability Scale

Definition
AI-generated

The liability scale is a latent continuous scale underlying a binary trait under threshold models, where disease occurs when an individual's liability exceeds a cutoff.

Topics
Probability and inference
Related
Case-Control Study Heritability Observed Scale

Why it matters in GWAS

Liability-scale conversion makes SNP heritability estimates for binary phenotypes more interpretable and more comparable across studies with different ascertainment fractions.

Example usage

"We reported SNP heritability on the liability scale using the assumed population prevalence."

Case-Control Study Heritability Observed Scale SNP Heritability
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Lee SH, et al. (2011). Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet.
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