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SLALOM

Definition
AI-generated

SLALOM is a quality-control framework for fine-mapping from summary statistics in meta-analyses of genome-wide association studies.

Topics
Population genetics
Related
Fine-Mapping from Summary Statistics GWAS Meta-Analysis GWAS Summary Statistics

Why it matters in GWAS

Mis-calibrated fine-mapping can over-confidence credible sets when meta-analyzed Z-scores are assembled from heterogeneous studies; SLALOM-style diagnostics motivate harmonization, stratified analysis, or multi-ancestry methods.

Example usage

"We ran SLALOM QC before reporting 95% credible sets from the trans-ethnic meta-analysis."

Fine-Mapping from Summary Statistics GWAS Meta-Analysis GWAS Summary Statistics Multi-Ancestry Fine-Mapping
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kanai M, et al. (2022). Meta-analysis fine-mapping is often miscalibrated at single-variant resolution. Cell Genom.
  • Li Z, Zhou X. (2025). Towards improved fine-mapping of candidate causal variants. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00869-4
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