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Multi-Ancestry Fine-Mapping

Definition
AI-generated

Multi-ancestry fine-mapping combines association and linkage-disequilibrium information from several ancestry groups to narrow candidate causal variants within a locus.

Topics
Population genetics
Synonyms
Trans-ancestry fine-mapping Trans-ethnic fine-mapping
Related
Fine-Mapping from Summary Statistics SuSiE Cross-Ancestry Genetic Correlation

Why it matters in GWAS

LD structure varies by ancestry; diverse panels can improve resolution of causal variants and gene prioritization for translation, complementing single-ancestry fine-mapping and meta-analysis of summary statistics.

Example usage

"We applied multi-ancestry fine-mapping across European, East Asian, and African ancestry GWAS to shrink the 95% credible set at the replicated locus."

Fine-Mapping from Summary Statistics SuSiE Cross-Ancestry Genetic Correlation Cross-Population Effect Heterogeneity Fine-Mapping Genome-Wide Association Study (GWAS) Linkage Disequilibrium (LD) Trans-Ancestry GWAS XMAP
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Gao B, Zhou X. (2024). MESuSiE enables scalable and powerful multi-ancestry fine-mapping of causal variants in genome-wide association studies. Nat Genet.
  • Yuan K, et al. (2024). Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases. Nat Genet.
  • Li Z, Zhou X. (2025). Towards improved fine-mapping of candidate causal variants. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00869-4
  • Asimit JL, et al. (2016). Trans-ethnic study design approaches for fine-mapping. Eur J Hum Genet.
  • Kuchenbaecker K, Navoly G. (2026). Ancestral diversity in complex disease genetics: from discovery to translation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00921-3
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