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Regional Plot

Definition
AI-generated

A regional plot is a locus-level visualization of association results around a lead variant.

Topics
Visualization
Synonyms
Locus plot
Related
ggplot2 Matplotlib Fine-Mapping

Why it matters in GWAS

Manhattan plots show genome-wide context, but regional plots reveal local structure: whether there is one narrow peak or several correlated signals, how far the association extends, and which genes lie nearby. They are standard for fine-mapping, colocalization, and manuscript figures focused on a specific locus.

Example usage

"A regional plot around the lead SNP showed a tight LD block overlapping the promoter of the candidate gene."

ggplot2 Matplotlib Fine-Mapping GWAS Summary Statistics gwaslab Linkage Disequilibrium (LD) Manhattan Plot Quantile-quantile plot (QQ plot)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Pruim RJ, et al. (2010). LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics. https://doi.org/10.1093/bioinformatics/btq419
  • GWASTutorial: Visualization by gwaslab.
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