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Pan-UK Biobank

Definition
AI-generated

Pan-UK Biobank denotes large-scale genome-wide association analyses in UK Biobank that stratify or jointly model multiple ancestry groups within the resource, aiming to reduce European-centric bias in discovery and to characterize ancestry-enriched or ancestry-specific effects while using a shared phenotyping framework.

Topics
Cohorts and databases
Related
Ancestry Global Biobank Meta-analysis Initiative (GBMI) Multi-Ancestry Fine-Mapping

Why it matters in GWAS

It provides complementary summary statistics and locus lists to European-majority UKB GWAS, supporting trans-ancestry comparison, multi-ancestry fine-mapping, and evaluation of polygenic risk score portability when combined with external cohorts.

Example usage

"We compared lead SNPs from Pan-UK Biobank South Asian stratum results with our Pakistani cohort for replication."

Ancestry Global Biobank Meta-analysis Initiative (GBMI) Multi-Ancestry Fine-Mapping Polygenic Risk Score Portability Trans-Ancestry GWAS UK Biobank
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Karczewski KJ, et al. (2025). Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects. Nat Genet.
  • Kuchenbaecker K, Navoly G. (2026). Ancestral diversity in complex disease genetics: from discovery to translation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00921-3
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