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Odds Ratio (OR)

Definition
AI-generated

The odds ratio compares the odds of disease between genotype groups; in GWAS it is typically the per-allele OR from logistic regression in unrelated case-control data (coding one allele as the effect).

Topics
Epidemiology
Related
Additive Genetic Model Case-Control Study Effect Allele

Why it matters in GWAS

OR is the standard summary for binary traits; for rare diseases, OR approximates relative risk when event rates are low. Meta-analysis combines log ORs with inverse-variance weights.

Example usage

"The lead SNP had OR = 1.08 per risk allele (95% CI 1.06-1.10)."

Additive Genetic Model Case-Control Study Effect Allele Effect Size Measure of effect
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References

← Odds Okazaki fragment →

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