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Case-Control Study

Definition
AI-generated

A case-control design compares unrelated affected cases to unaffected controls, estimating genotype frequencies or odds ratios.

Topics
Epidemiology
Related
Additive Genetic Model Cohort Participation Bias

Why it matters in GWAS

Logistic regression yields log odds ratios per allele; liability-scale interpretation and power differ from quantitative-trait linear regression and depend on prevalence and sampling.

Example usage

"The primary case-control study compared allele frequencies between diagnosed participants and matched controls."

Additive Genetic Model Cohort Participation Bias Proxy Phenotype Firth Regression Odds Ratio (OR) Trait Transmission Disequilibrium Test (TDT)
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References

← Case-Control Imbalance Categorical distribution →

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