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Net Reclassification Improvement (NRI)

Definition
AI-generated

Net reclassification improvement summarizes how much a prediction model with an added predictor (e.g. a polygenic risk score) changes risk categories relative to a baseline model, net of incorrect moves across categories; it complements discrimination metrics such as AUC.

Topics
Probability and inference
Synonyms
NRI
Related
Absolute Risk Area Under the ROC Curve (AUC) Case-Control Study

Why it matters in GWAS

PRS and integrated clinical–genetic models are often evaluated for clinical utility; NRI and related metrics appear in discussions of whether new genetic information meaningfully reclassifies individuals for prevention or treatment decisions.

Example usage

"Downstream interpretation uses Net Reclassification Improvement (NRI) to link statistical findings to biological context."

Absolute Risk Area Under the ROC Curve (AUC) Case-Control Study Decision Curve Analysis Measure of Effect Polygenic Risk Score (PRS) Pseudo-R² Risk Stratification
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References

  • Pencina MJ, et al. (2008). Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med.
  • Uffelmann E, et al. (2021). Genome-wide association studies. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-021-00056-9
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