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Area Under the ROC Curve (AUC)

Definition
AI-generated

The area under the receiver operating characteristic (ROC) curve (AUC) summarizes how well a predictor—such as a polygenic risk score—separates cases from controls across all possible classification thresholds.

Topics
Probability and inference
Synonyms
AUROC C-statistic (binary outcomes, common usage)
Related
Calibration Case-Control Study Decision Curve Analysis

Why it matters in GWAS

AUC is a standard discrimination metric for PRS evaluation alongside R² and liability-scale measures; it does not by itself address calibration or clinical utility without absolute risk context.

Example usage

"The T2D PRS achieved AUC = 0.62 in the held-out African-ancestry target, lower than in Europeans."

Calibration Case-Control Study Decision Curve Analysis Net Reclassification Improvement (NRI) Polygenic Risk Score (PRS) Polygenic Risk Score Portability Pseudo-R²
Related-term network

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References

  • Kachuri L, Chatterjee N, Hirbo J, et al. (2024). Principles and methods for transferring polygenic risk scores across global populations. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00637-2
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