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Absolute Risk

Definition
AI-generated

Absolute risk is the probability that an individual who is disease-free at baseline will develop the outcome over a defined follow-up period, often expressed as a percentage.

Topics
Epidemiology
Related
Case-Control Study Net Reclassification Improvement (NRI) Odds Ratio (OR)

Why it matters in GWAS

Polygenic scores are often evaluated first for association and discrimination, but clinical and public-health interpretation requires calibration to absolute risk in the target population, accounting for prevalence, age, sex, and other risk factors.

Example usage

"We combined the breast cancer PRS with the Tyrer–Cuzick model to report 10-year absolute risk by PRS decile."

Case-Control Study Net Reclassification Improvement (NRI) Odds Ratio (OR) Polygenic Risk Score (PRS) Polygenic Risk Score Portability Risk Stratification
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kachuri L, Chatterjee N, Hirbo J, et al. (2024). Principles and methods for transferring polygenic risk scores across global populations. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00637-2
  • Chatterjee N, Shi J, García-Closas M. (2016). Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat Rev Genet.
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