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Mendelian Error

Definition
AI-generated

A Mendelian error (Mendelian inconsistency) is a genotype configuration in a trio or pedigree that violates Mendelian transmission—for example, a child whose genotype cannot be produced from the called parental genotypes at that locus.

Topics
GWAS
Synonyms
Mendelian inconsistency
URL
https://www.cog-genomics.org/plink/1.9/filter#me
Related
Pedigree PLINK Quality Control (QC)

Why it matters in GWAS

Mendelian checks catch sample swaps, pedigree mistakes, and poor genotype calls; systematic errors can bias family-based tests and undermine trust in trio or duos QC.

Example usage

"The interpretation of inheritance patterns explicitly references Mendelian Error in the pedigree analysis."

Pedigree PLINK Quality Control (QC)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • PLINK 1.9 Mendel errors: https://www.cog-genomics.org/plink/1.9/filter#me
  • PLINK 2.0 --mendel / --me: https://www.cog-genomics.org/plink/2.0/filter#me
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