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Mendelian law of inheritance

Definition
AI-generated

Core Mendelian rules—segregation, dominance, and independent assortment—that describe transmission at single-gene resolution under idealized assumptions.

Topics

Why it matters in GWAS

These concepts shape how we expect variants to act (penetrance, heterogeneity, threshold models) and how GWAS signals should be interpreted alongside family-based evidence.

Example usage

"The interpretation of inheritance patterns explicitly references Mendelian law of inheritance in the pedigree analysis."

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.

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