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Lipid Quantitative Trait Locus

Definition
AI-generated

A lipid quantitative trait locus (lipid QTL) is a genetic variant associated with a specific lipid species or lipidomic feature—often from mass spectrometry lipidomics—rather than only clinical total cholesterol or LDL-C.

Topics
Core genetics
Related
Lipidome Lipidomics Metabolite Quantitative Trait Locus (metaboQTL)

Why it matters in GWAS

Lipid QTLs refine metabolic mechanisms at GWAS loci by pointing to particular molecular lipid classes (e.g. ceramides, plasmalogens) that aggregate measures can obscure.

Example usage

"A replication step checks whether Lipid Quantitative Trait Locus assumptions remain stable across cohorts."

Lipidome Lipidomics Metabolite Quantitative Trait Locus (metaboQTL) Metabolome
Related-term network

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References

  • Kettunen J, et al. (2016). Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun.
← Linkage Disequilibrium (LD) Lipidome →

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