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Lipidome

Definition
AI-generated

The lipidome is the complete set of lipid species in a biosample (e.g. plasma, tissue), profiled by mass spectrometry–based lipidomics platforms that resolve molecular lipid classes and chain compositions.

Topics
Sequencing and omics tech
Related
Lipid Quantitative Trait Locus Lipidomics Metabolome

Why it matters in GWAS

Lipid species are highly heritable molecular traits; mapping lipid QTLs alongside clinical lipid GWAS refines pathway mechanisms (e.g. fatty acid elongation, lipoprotein remodeling) beyond aggregate cholesterol measures.

Example usage

"The study quantified over 400 plasma lipid species to build a lipidome-wide genetic association resource."

Lipid Quantitative Trait Locus Lipidomics Metabolome Metabolite Quantitative Trait Locus (metaboQTL)
Related-term network

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References

  • Kettunen J, et al. (2016). Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun.
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