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Lipidomics

Definition
AI-generated

Lipidomics is the systematic measurement and analysis of lipid molecules and their distributions across pathways, often integrated with genetics as lipidome-wide association studies.

Why it matters in GWAS

Lipidomics connects cardiovascular and metabolic GWAS loci to specific molecular lipid intermediates, helping distinguish lipoprotein particle effects from enzymatic steps in fatty acid metabolism.

Example usage

"Lipidomics GWAS highlighted variants near elongase genes affecting very-long-chain ceramides."

References

  • Ahrends R, et al. (2019). Lipidomics in health and disease—subtle differences with dramatic impact. Nat Rev Endocrinol.

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